Hauv kev lag luam botanical extract, ob lub tshuab sau npe muaj cov khoom siv tshwj xeeb: "kev faib tawm" (piv txwv li, 10: 1, 20: 1) thiab "tus qauv rho tawm" (piv txwv li, flavonoids Ntau dua lossis sib npaug li 50% los ntawm HPLC). Thaum ob qho tib si zoo li piav qhia txog kev xav, lawv yog qhov sib txawv hauv qhov lawv tau lees paub-thiab qhov tseem ceeb tshaj, qhov lawv tsis lav.
Rau cov formulator ua haujlwm nrogHawthorn nplooj Extract hmoov, qhov kev sib txawv no tsis yog qhov theoretical- nws txiav txim siab seb cov khoom puas tau muab cov txiaj ntsig ntawm lub plawv los yog tsuas yog ua tau raws li qhov xav tau.
Qhov piv txwv Extracts tiag txhais tau li cas
Ratio rho tawm xws li 10: 1 lossis 20: 1 piav qhia atxheej txheem concentration, tsis muaj tshuaj lom neeg muaj pes tsawg leeg.
Piv txwv li:
10 kg ntawm raw tshuaj ntsuab → 1 kg extract (10: 1)
Tab sis qhov no tsis teb:
Muaj pes tsawg flavonoid nyob hauv?
Puas muaj cov flavonoids?
Puas yog cov tshuaj nquag khaws cia lossis degraded?
Qhov tseem ceeb txwv
Kev faib tawm piv piv xav tias "cov khoom siv raw=muaj zog dua," tab sis tsis quav ntsej:
Plant variability (lub caij, keeb kwm, maturity)
Extraction xaiv
Thaum tshav kub kub thiab hnyav degradation
Tsis yog - nquag nquag tsub zuj zuj (qab zib, fibers, resins)
👉 Qhov tshwm sim: Ob 10: 1 rho tawm tuaj yeem coj txawv txawv hauv kev tsim.
Dab tsi Standardized Extracts Guarantee
A txheem extractyog txhais los ntawm kev ntsuas cov ntsiab lus ntawm cov cim cim tshwj xeeb -cov khoom siv bioactive tau txheeb xyuas los ntawm kev tshuaj ntsuam xyuas. Rau hawthorn nplooj extract, qhov no feem ntau txhais tau hais tias tag nrho cov flavonoids quantified los ntawm HPLC (High-Performance Liquid Chromatography), xws li Ntau tshaj los yog sib npaug rau 50% los yog ntau tshaj los yog sib npaug rau 80% tag nrho flavonoids txheeb xyuas raws li rutin anhydrous .
Lub German Commission E monograph, dav suav hais tias yog tus qauv kub rau kev tshuaj xyuas tshuaj ntsuab, qhia meej meej yuav tsum muaj cov txheej txheem hawthorn extracts nrog "txhais flavonoid lossis oligomeric procyanidin cov ntsiab lus". Cov kev tshawb fawb soj ntsuam pom tau hais tias hawthorn cov txiaj ntsig ntawm lub plawv tau siv tsis tu ncua cov txheej txheem rho tawm -tsis piv cov rho tawm .
Kev faib tawm Analytical: UV vs HPLC
Txoj kev siv los txheeb xyuas cov khoom sib txuas tseem ceeb yog qhov tseem ceeb raws li tus qauv nws tus kheej. Ntau tus neeg muag khoom siv UV spectrophotometry, uas ntsuas tag nrho cov phenolics dav thiab feem ntau overestimates flavonoid cov ntsiab lus. HPLC, los ntawm qhov sib txawv, cais thiab ntsuas cov neeg sib txuas nrog qhov tseeb, muab qhov tseeb "tus ntiv tes" ntawm cov khoom sib xyaw.
Rau cov neeg yuav khoom B2B, qhov kev sib txawv no muaj qhov cuam tshuam rau kev tswj hwm. Cov koom haum tswj hwm nce ntxiv yuav tsum tau HPLC-raws li cov ntaub ntawv rau kev sau npe ntawm cov khoom lag luam thiab thov cov ntaub ntawv pov thawj. COA (Certificate of Analysis) raws li HPLC muab pov thawj tiv thaiv; ib tug raws li UV tsis.
Vim li cas qhov no tseem ceeb?
nlike ratio extracts, standardized extracts xyuas kom meej:
Txhais pharmacological cim
Batch-rau-batch sib xws
Predictable lom kev ua si
👉 Hauv luv luv: Kev ntsuas ntsuas "qhov tseem ceeb," tsis yog "cov khoom siv raw li cas."
Kab hauv qab
| Yam | Ratio Extract | Standardized Extract |
|---|---|---|
| Txhais | Qhov hnyav piv ntawm raw khoom rau extract | Ntsuas cov ntsiab lus ntawm active compounds |
| Cov ntsiab lus nquag | Tsis tau guaranteed, kuj txawv txav | Txheeb xyuas los ntawm HPLC, batch-to-batch zoo ib yam |
| Cov pov thawj kho mob | Txwv tsis pub, kev tshawb fawb siv cov qauv tsim | Txhawb los ntawm kev tshawb fawb soj ntsuam |
| Kev them nyiaj yug Regulatory | Tsis muaj zog, nyuaj rau substantiate thov | Muaj zog, muab cov ntaub ntawv tiv thaiv |
| Formulation Reliability | Unpredictable | Predictable thiab reproducible |
Formulation Reality: Yog vim li cas Standardization tseem ceeb dua puas tau
Hauv cov dej haus, tshuaj ntsiav, thiab hmoov, cov neeg tsim khoom ntsib peb qhov teeb meem tseem ceeb:
1) Kev ruaj ntseg
Flavonoids degrade hauv qab no:
kub
oxygen
pH variation
Standardized extracts cia zoo kwv yees ntawm degradation kinetics.
2) Solubility & Zoo
Ratio extracts feem ntau muaj:
insoluble feem
waxes thiab resins
Qhov no ua rau:
huab
sedimentation
instability hauv RTD dej haus
3) Dosage Accuracy
Tsis muaj standardization:
100 mg extract ≠ 100 mg active compounds
Kev siv tshuaj kho mob yuav tsis ntseeg tau
Xaus
Kev lag luam tab tom hloov ntawm "kev xav ntau" mus rau "zoo txhais."
Ratio extracts belongs rau ib tug legacy extraction mindset qhov twg concentration yog assumed mus sib npaug zos potency. Txawm li cas los xij, kev txhim kho cov khoom xyaw niaj hnub no-tshwj xeeb tshaj yog rau Hawthorn Leaf Extract Powder- yuav tsum muaj kev kwv yees txog kev noj qab haus huv, kev tswj kom meej meej, thiab kev ruaj ntseg.
Standardized extracts tsis yog ib qho kev hloov kho tshiab -lawv yog ib qho tseem ceeb rau kev txhim kho cov khoom lag luam txhim khu kev qha.
FAQ
01.Dab tsi yog qhov sib txawv tseem ceeb ntawm qhov sib piv ntawm cov extract thiab cov txheej txheem extract?
02.Puas yog qhov sib piv ntau dua (piv txwv li, 20: 1) txhais tau tias muaj zog dua?
03.Vim li cas HPLC standardization tseem ceeb?
04.Puas piv cov extracts tseem siv tau rau hauv cov tshuaj?
05.Qhov twg zoo dua rau cov dej haus ua haujlwm?
06.Does standardization nce nqi?
Cov ntaub ntawv
1.Blumenthal M, Busse WR, Goldberg A, thiab al., editors.Ua tiav German Commission E Monographs: Therapeutic Guide to Herbal Medicines[M]. Austin, TX: American Botanical Council; Xyoo 1998.
2.Blumenthal M, et al., editors. "Hawthorn nplooj nrog paj" [M]. Hauv:Ua tiav German Commission E Monographs. Austin, TX: American Botanical Council; Xyoo 1998.
3.Hawthorn [M]. Hauv:ABC Clinical Guide to Herbs. Austin, TX: American Botanical Council; Xyoo 2003.
4.Sagaradze VA, Babaeva EY, et al. HPLC-UV txoj kev txiav txim siab flavonoids hauv hawthorn paj thiab nplooj [J].Pharmaceutical Chemistry Journal, 2017, 51(4): 104-112.
5. Wang SY, et al. HPLC kev txiav txim siab ntawm tsib polyphenols nyob rau hauv nas ntshav tom qab txhaj tshuaj ntawm hawthorn nplooj extract thiab nws daim ntawv thov rau pharmacokinetic kawm [J].Yakugaku Zasshi, 2010, 130(11).
6. Pharmacy & Pharmacology. Kev sib piv ntawm hawthorn raw khoom standardization mus kom ze nyob rau hauv txawv pharmacopoeias [J].Pharmacy & Pharmacology, 2018, 6(2): 104-120.
7. Suav Pharmocopoeia Commission.Pharmacopoeia ntawm Cov Neeg Koom pheej ntawm Tuam Tshoj(2020 Edition) [S]. Beijing: Tuam Tshoj Medical Science Xovxwm; 2020.
8. Guo Y, et al. Tshuaj muaj pes tsawg leeg, bioactivities, thiab cov qauv zoo ntawm hawthorn nplooj: kev tshuaj xyuas [J].Frontiers hauv Pharmacology, 2023, 14: 1275244.
9.Sagaradze VA, et al. HPLC-UV txoj kev txiav txim siab flavonoids hauv hawthorn paj thiab nplooj [J].Pharmaceutical Chemistry Journal, 2017, 51(4): 104-112. (Kev xa mus rau Belarusian Pharmacopoeia txoj kev)
10.Sagaradze VA, et al. HPLC-UV txoj kev txiav txim siab flavonoids hauv hawthorn paj thiab nplooj [J].Pharmaceutical Chemistry Journal, 2017, 51(4): 104-112. (Referencing European Pharmacopoeia txoj kev)
